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Loredana Fiorentino, Michele Cavalera, Stefano Menini, Valentina Marchetti, Maria Mavilio, Marta Fabrizi, Francesca Conserva, Viviana Casagrande, Rossella Menghini, Paola Pontrelli, Ivan Arisi, Mara D'Onofrio, Davide Lauro, Rama Khokha, Domenico Accili, Giuseppe Pugliese, Loreto Gesualdo, Renato Lauro and Massimo Federici Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay EMBO Molecular Medicine 5

Article first published online: 12 FEB 2013 | DOI: 10.1002/emmm.201201475

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Loss of TIMP3 is a hallmark of diabetic kidney disease in human and mouse models. Concomitant STAT1-dependent loss of FoxO1 activity modulates expression of oxidative and protective autophagy genes and results in glomeruli damage.

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