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Pei-Tzu Yang, Jamie N. Anastas, Rachel A. Toroni, Michi M. Shinohara, Jamie M. Goodson, Anja K. Bosserhoff, Andy J. Chien and Randall T. Moon WLS inhibits melanoma cell proliferation through the β-catenin signalling pathway and induces spontaneous metastasis EMBO Molecular Medicine 4

Version of Record online: 6 NOV 2012 | DOI: 10.1002/emmm.201201486

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Even though WNT/ β-catenin signaling is downregulated, malignant melanomas express high levels of WNT ligands. Here, the authors show that reduced expression of the WNT secretory receptor WLS could be the cause of loss of WNT/β-catenin signaling.

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