Naomi Pode-Shakked, Rachel Shukrun, Michal Mark-Danieli, Peter Tsvetkov, Sarit Bahar, Sara Pri-Chen, Ronald S. Goldstein, Eithan Rom-Gross, Yoram Mor, Edward Fridman, Karen Meir, Amos Simon, Marcus Magister, Naftali Kaminski, Victor S. Goldmacher, Orit Harari-Steinberg and Benjamin Dekel The isolation and characterization of renal cancer initiating cells from human Wilms' tumour xenografts unveils new therapeutic targets EMBO Molecular Medicine 5
Article first published online: 13 DEC 2012 | DOI: 10.1002/emmm.201201516
Here, the authors report the isolation and characterisation of Wilms' tumour stem cells and show that targeting a cancer cell population enriched for cancer-initiating cell activity leads to tumour eradication in a mouse model.
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