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Petra Simic, Kayvan Zainabadi, Eric Bell, David B. Sykes, Borja Saez, Sutada Lotinun, Roland Baron, David Scadden, Ernestina Schipani and Leonard Guarente SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin EMBO Molecular Medicine 5

Version of Record online: 30 JAN 2013 | DOI: 10.1002/emmm.201201606

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The authors show that in mesenchymal stem cells, SIRT1 deacetylates β-catenin to trigger its nuclear translocation and activation of genes for differentiation.

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