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Fei Xing, Aya Kobayashi, Hiroshi Okuda, Misako Watabe, Sudha K. Pai, Puspa R. Pandey, Shigeru Hirota, Andrew Wilber, Yin-Yuan Mo, Brian E. Moore, Wen Liu, Koji Fukuda, Megumi Iiizumi, Sambad Sharma, Yin Liu, Kerui Wu, Elizabeth Peralta and Kounosuke Watabe Reactive astrocytes promote the metastatic growth of breast cancer stem-like cells by activating Notch signalling in brain EMBO Molecular Medicine 5

Version of Record online: 5 MAR 2013 | DOI: 10.1002/emmm.201201623

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In the mouse brain, metastatic breast cancer cells secrete IL-1beta, which induces the Notch pathway promoting breast cancer cell stemness and thereby leading to metastasis. The Notch inhibitor Compound E is shown to suppress brain metastasis growth.

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