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Michel Obeid, Jean-François Franetich, Audrey Lorthiois, Audrey Gego, Anne Charlotte Grüner, Maurel Tefit, Claude Boucheix, Georges Snounou and Dominique Mazier Skin-draining lymph node priming is sufficient to induce sterile immunity against pre-erythrocytic malaria EMBO Molecular Medicine 5

Version of Record online: 19 DEC 2012 | DOI: 10.1002/emmm.201201677

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Priming in the skin with the antigens present in, or derived from, live attenuated sporozoites is shown to confer sterile protection. This provides proof-of-principle for a new anti-infection vaccination strategy based on skin-based immune responses.

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