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Christoph Burkart, Kei-ichiro Arimoto, Tingdong Tang, Xiuli Cong, Nengming Xiao, Yun-Cai Liu, Sergei V. Kotenko, Lesley G. Ellies and Dong-Er Zhang Usp18 deficient mammary epithelial cells create an antitumour environment driven by hypersensitivity to IFN-λ and elevated secretion of Cxcl10 EMBO Molecular Medicine 5

Article first published online: 16 MAY 2013 | DOI: 10.1002/emmm.201201864

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Usp18 regulates the mammary tumor microenvironment via IFN-λ signalling in epithelial cells: secreted Cxcl10 attract Th1 cells that will block tumor growth. These findings provide new candidates for epithelial breast cancer immunotherapy.

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