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Nambirajan Govindarajan, Pooja Rao, Susanne Burkhardt, Farahnaz Sananbenesi, Oliver M. Schlüter, Frank Bradke, Jianrong Lu and André Fischer Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease EMBO Molecular Medicine 5

Article first published online: 26 NOV 2012 | DOI: 10.1002/emmm.201201923

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The authors identified HDAC6 as a novel therapeutic target in Alzheimer's disease. Reducing HDAC6 protein levels in the brains of an AD mouse model improves memory and protects neurons against amyloid-β-induced impairment of mitochondrial trafficking.

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