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Jiyoung Park, Thomas S. Morley and Philipp E. Scherer Inhibition of endotrophin, a cleavage product of collagen VI, confers cisplatin sensitivity to tumours EMBO Molecular Medicine 5

Article first published online: 30 APR 2013 | DOI: 10.1002/emmm.201202006

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Endotrophin, secreted from stromal adipocytes in the tumor microenvironment, confers cisplatin resistance by enhancing EMT, fibrosis and angiogenesis. Thiazolidinediones neutralize endotrophin activities and improve the therapeutic response.

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