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Rajan Gogna, Esha Madan, Mahmood Khan, Uttam Pati and Periannan Kuppusamy p53's choice of myocardial death or survival: Oxygen protects infarct myocardium by recruiting p53 on NOS3 promoter through regulation of p53-Lys118 acetylation EMBO Molecular Medicine 5

Version of Record online: 1 OCT 2013 | DOI: 10.1002/emmm.201202055

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Oxygen therapy of infarcted hearts is shown to lead to increased survival of cardiomyocytes, inhibition of p53-dependent apoptosis mediated by p53-Lys118 and high expression of NOS3 via p53-dependent transcription and improved cardiac function.

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