Ivan Nemazanyy, Bert Blaauw, Cecilia Paolini, Catherine Caillaud, Feliciano Protasi, Amelie Mueller, Tassula Proikas-Cezanne, Ryan C. Russell, Kun-Liang Guan, Ichizo Nishino, Marco Sandri, Mario Pende and Ganna Panasyuk Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease EMBO Molecular Medicine 5
Article first published online: 30 APR 2013 | DOI: 10.1002/emmm.201202057
Mice lacking Vps15 in skeletal muscles develop the pathological features of autophagic vacuolar myopathy (AVM). Vps34/Vps15 complex activity is shown to be critical in disease conditions such as AVMs, and possibly other lysosomal storage diseases.
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