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Nathalie Pierrot, Donatienne Tyteca, Ludovic D'auria, Ilse Dewachter, Philippe Gailly, Aurélie Hendrickx, Bernadette Tasiaux, Laetitia El Haylani, Nathalie Muls, Francisca N'Kuli, Annie Laquerrière, Jean-Baptiste Demoulin, Dominique Campion, Jean-Pierre Brion, Pierre J. Courtoy, Pascal Kienlen-Campard and Jean-Noël Octave Amyloid precursor protein controls cholesterol turnover needed for neuronal activity EMBO Molecular Medicine 5

Version of Record online: 2 APR 2013 | DOI: 10.1002/emmm.201202215

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GWAS identified components of the cholesterol metabolism machinery as important risk factors for Alzheimer's disease. APP is shown here to control neuronal cholesterol turnover, which highlight therapeutic alternatives for AD treatment.

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