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Joachim Albers, Michal Rajski, Désirée Schönenberger, Sabine Harlander, Peter Schraml, Adriana von Teichman, Strahil Georgiev, Peter J. Wild, Holger Moch, Wilhelm Krek and Ian J. Frew Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice EMBO Molecular Medicine 5

Version of Record online: 22 APR 2013 | DOI: 10.1002/emmm.201202231

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The Authors demonstrate that secondary genetic alterations can cooperate with loss of VHL to cause kidney tumour formation and implicate TP53 mutations in the pathogenesis of a subset of clear cell renal cell carcinomas in humans.

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