Veronika Hampl, Claudia Martin, Achim Aigner, Sabrina Hoebel, Stephan Singer, Natalie Frank, Antonio Sarikas, Oliver Ebert, Ron Prywes, Thomas Gudermann and Susanne Muehlich Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence EMBO Molecular Medicine 5
Article first published online: 29 JUL 2013 | DOI: 10.1002/emmm.201202406
MKL1 and 2 are promising novel therapeutic targets in DLC1-deficient hepatocellular carcinoma. As tumor suppressors such as DLC1 are generally not amenable to direct therapeutic targeting, targeting of MKL1∕2 might bear enormous potential.
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