Cathal McCarthy, Nora T. Lieggi, Denis Barry, Declan Mooney, Monica de Gaetano, William G. James, Sarah McClelland, Mary C. Barry, Laure Escoubet-Lozach, Andrew C. Li, Christopher K Glass, Desmond J. Fitzgerald and Orina Belton Macrophage PPAR gamma Co-activator-1 alpha participates in repressing foam cell formation and atherosclerosis in response to conjugated linoleic acid EMBO Molecular Medicine 5
Version of Record online: 21 AUG 2013 | DOI: 10.1002/emmm.201302587
CLA inhibition of foam cell formation is linked to induction of PGC-1α and macrophage specific deletion of PGC-1α increases atherosclerosis in vivo. PGC-1α is expressed in patient plaques, suggesting that it is a regulatory pathway in atherosclerosis.
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