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Ana I Arroyo, Paola G Camoletto, Laura Morando, Marco Sassoe-Pognetto, Maurizio Giustetto, Paul P Van Veldhoven, Edward H Schuchman and Maria D Ledesma Pharmacological reversion of sphingomyelin-induced dendritic spine anomalies in a Niemann Pick disease type A mouse model EMBO Molecular Medicine 6

Article first published online: 21 JAN 2014 | DOI: 10.1002/emmm.201302649

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A novel pathway is described in a Niemann Pick mouse model whereby elevated sphingomyelin impairs dendritic spines by modulating the actin cytoskeleton. Pharmacological activation of sphingomyelin catabolism in vivo with dexamethasone ameliorates the pathology of affected mice.

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