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Nina Cabezas-Wallscheid, Victoria Eichwald, Jos de Graaf, Martin Löwer, Hans-Anton Lehr, Andreas Kreft, Leonid Eshkind, Andreas Hildebrandt, Yasmin Abassi, Rosario Heck, Anna Katharina Dehof, Svetlana Ohngemach, Rolf Sprengel, Simone Wörtge, Steffen Schmitt, Johannes Lotz, Claudius Meyer, Thomas Kindler, Dong-Er Zhang, Bernd Kaina, John C. Castle, Andreas Trumpp, Ugur Sahin and Ernesto Bockamp Instruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mouse model EMBO Molecular Medicine 5

Version of Record online: 4 OCT 2013 | DOI: 10.1002/emmm.201302661

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This novel model system of AML1-ETO driven acute myeloid leukaemia addresses the concept of ‘oncogene addiction’. Better understanding of AML1-ETO need to maintain leukemia and rewire the transcriptome may help to design future therapies.

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