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Florian Sennlaub, Constance Auvynet, Bertrand Calippe, Sophie Lavalette, Lucie Poupel, Shulong J. Hu, Elisa Dominguez, Serge Camelo, Olivier Levy, Elodie Guyon, Noah Saederup, Israel F. Charo, Nico Van Rooijen, Emeline Nandrot, Jean-Louis Bourges, Francine Behar-Cohen, José-Alain Sahel, Xavier Guillonneau, William Raoul and Christophe Combadiere CCR2+ monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice EMBO Molecular Medicine 5

Article first published online: 21 OCT 2013 | DOI: 10.1002/emmm.201302692

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The eyes of patients with atrophic AMD feature high CCL2 and CCR2+ monocytes. This is modeled in Cx3cr1 KO mice in which Ccl2 and Ccr2 deletion, CCR2 inhibition and monocyte depletion diminished subretinal inflammation and photoreceptor degeneration.

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