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Norbert Odolczyk, Janine Fritsch, Caroline Norez, Nathalie Servel, Melanie Faria da Cunha, Sara Bitam, Anna Kupniewska, Ludovic Wiszniewski, Julien Colas, Krzysztof Tarnowski, Danielle Tondelier, Ariel Roldan, Emilie L. Saussereau, Patricia Melin-Heschel, Grzegorz Wieczorek, Gergely L. Lukacs, Michal Dadlez, Grazyna Faure, Harald Herrmann, Mario Ollero, Frédéric Becq, Piotr Zielenkiewicz and Aleksander Edelman Discovery of novel potent ΔF508-CFTR correctors that target the nucleotide binding domain EMBO Molecular Medicine 5

Article first published online: 27 AUG 2013 | DOI: 10.1002/emmm.201302699

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A virtual screening strategy led to potent novel compounds (correctors), able to correct the function of mutant (ΔF508-CFTR) CFTR and based on their ability to inhibit interactions between mutant ΔF508-CFTR and keratin 8.

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