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Rossella Lucá, Michele Averna, Francesca Zalfa, Manuela Vecchi, Fabrizio Bianchi, Giorgio La Fata, Franca Del Nonno, Roberta Nardacci, Marco Bianchi, Paolo Nuciforo, Sebastian Munck, Paola Parrella, Rute Moura, Emanuela Signori, Robert Alston, Anna Kuchnio, Maria Giulia Farace, Vito Michele Fazio, Mauro Piacentini, Bart De Strooper, Tilmann Achsel, Giovanni Neri, Patrick Neven, D. Gareth Evans, Peter Carmeliet, Massimiliano Mazzone and Claudia Bagni The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation EMBO Molecular Medicine 5

Version of Record online: 16 SEP 2013 | DOI: 10.1002/emmm.201302847

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The fragile X mental retardation protein (FMRP) is shown for the first time with a role in breast cancer progression. FMRP is further shown to drive EMT by binding to and regulating vimentin and E-cadherin suggesting a role in metastasis formation.

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