Ju Cao, Dongsheng Wang, Fang Xu, Yi Gong, Hong Wang, Zixin Song, Dageng Li, Hua Zhang, Dairong Li, Liping Zhang, Yun Xia, Huajian Xu, Xaiofei Lai, Shihui Lin, Xuemei Zhang, Guosheng Ren, Yubing Dai and Yibing Yin Activation of IL-27 signalling promotes development of postinfluenza pneumococcal pneumonia EMBO Molecular Medicine 6
Article first published online: 29 OCT 2013 | DOI: 10.1002/emmm.201302890
Influenza infection is shown to induce pulmonary IL27 production in an IFNAR-dependent manner, by directly and indirectly suppressing IL17A production by γδ T cells, which result in increased sensitivity to secondary pneumococcal infection in vivo.
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