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Katrin Kollmann, Jan Malte Pestka, Sonja Christin Kühn, Elisabeth Schöne, Michaela Schweizer, Kathrin Karkmann, Takanobu Otomo, Philip Catala-Lehnen, Antonio Virgilio Failla, Robert Percy Marshall, Matthias Krause, Rene Santer, Michael Amling, Thomas Braulke and Thorsten Schinke Decreased bone formation and increased osteoclastogenesis cause bone loss in mucolipidosis II EMBO Molecular Medicine 5

Version of Record online: 15 OCT 2013 | DOI: 10.1002/emmm.201302979

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Dysfunctional osteoblasts and the Il-6-driven osteoclast increase rather than lysosomal hydrolase missorting underlie the osteoporotic phenotype in a mouse model of mucolipidosis II. Bisphosphonate treatment increased bone density and stabilization.

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