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Yasir A. Syed, Alexandra Baer, Matthias P. Hofer, Ginez A. González, Jon Rundle, Szymon Myrta, Jeffrey K. Huang, Chao Zhao, Moritz J. Rossner, Matthew W. B. Trotter, Gert Lubec, Robin J. M. Franklin and Mark R. Kotter Inhibition of phosphodiesterase-4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination EMBO Molecular Medicine 5

Version of Record online: 21 OCT 2013 | DOI: 10.1002/emmm.201303123

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Mechanisms of re-myelination failure in multiple sclerosis for example remain incompletely understood. Here, phosphodiesterase Pde4 inhibition is shown to increase OPC differentiation and remyelination via cAMP-Erk1/2/p38Mapk-Creb1 signaling axis.

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