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Benjamin Uzan, Sandrine Poglio, Bastien Gerby, Ching-Lien Wu, Julia Gross, Florence Armstrong, Julien Calvo, Xavier Cahu, Caroline Deswarte, Florent Dumont, Diana Passaro, Corinne Besnard-Guérin, Thierry Leblanc, André Baruchel, Judith Landman-Parker, Paola Ballerini, Véronique Baud, Jacques Ghysdael, Frédéric Baleydier, Francoise Porteu and Francoise Pflumio Interleukin-18 produced by bone marrow-derived stromal cells supports T-cell acute leukaemia progression EMBO Molecular Medicine 6

Version of Record online: 28 APR 2014 | DOI: 10.1002/emmm.201303286

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Chemical inhibition of MEK induces growth of human T-cell acute leukaemia (T-ALL) cells via the release of pro-inflammatory IL-18 by bone marrow-derived stromal cells in the tumour microenvironment.

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