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Guntur Fibriansah, Joanne L Tan, Scott A Smith, Adamberage R de Alwis, Thiam-Seng Ng, Victor A Kostyuchenko, Kristie D Ibarra, Jiaqi Wang, Eva Harris, Aravinda de Silva, James E Crowe Jr and Shee-Mei Lok A potent anti-dengue human antibody preferentially recognizes the conformation of E protein monomers assembled on the virus surface EMBO Molecular Medicine 6

Version of Record online: 14 JAN 2014 | DOI: 10.1002/emmm.201303404

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Vaccine development against Dengue disease is complicated by the virus serotype priming to secondary infections. Structure of a potent human antibody 1F4 complexed with DENV serotype 1 highlights the hinge angle of the viral protein as critical for vaccine design.

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