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Marco Discacciati, David Hacker, Alfio Quarteroni, Samuel Quinodoz, Stéphanie Tissot and Florian M. Wurm Numerical simulation of orbitally shaken viscous fluids with free surface International Journal for Numerical Methods in Fluids 71

Version of Record online: 14 FEB 2012 | DOI: 10.1002/fld.3658

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Orbitally shaken bioreactors are an emerging alternative to stirred-tank bioreactors for large-scale mammalian cell culture, but their fluid dynamics is still not well-defined. Among the theoretical and practical issues that remain to be resolved, the characterization of the liquid free surface during orbital shaking remains a major challenge because it is an essential aspect of gas transfer and mixing in these reactors.

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