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Geng Chen, Chengxiang Qiu, Qipeng Zhang, Bing Liu and Qinghua Cui Genome-Wide Analysis of Human SNPs at Long Intergenic Noncoding RNAs Human Mutation 34

Article first published online: 27 NOV 2012 | DOI: 10.1002/humu.22239

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A genome-wide analysis of human SNPs at long intergenic noncoding RNAs (lincRNAs) revealed a significantly lower SNP density in lincRNA regions than flanking regions. However, the lincRNAs under recent positive selection have higher SNP density than flanking regions. Functional regions show lower SNP density than other regions in lincRNAs. We revealed that SNP density of lincRNAs is correlated with expression level and tissue specificity. We provided evidence that lincRNA SNP can affect phenotype and be associated with disease.

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