Daniela T. Soltys, Clarissa R. R. Rocha, Letícia K. Lerner, Tiago A. de Souza, Veridiana Munford, Fernanda Cabral, Tiziana Nardo, Miria Stefanini, Alain Sarasin, Januário B. Cabral-Neto and Carlos F. M. Menck Novel XPG (ERCC5) Mutations Affect DNA Repair and Cell Survival after Ultraviolet but not Oxidative Stress Human Mutation 34
Article first published online: 17 JAN 2013 | DOI: 10.1002/humu.22259
Two novel XPG mutations were detected from patients with mild xeroderma pigmentosum phenotype. Functional analyses demonstrate these novel mutations lead to important reduction capacity in the repair of UV-induced DNA lesions, but do not affect the repair of oxidatively generated DNA lesions.
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