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James G. Dowty, Aung K. Win, Daniel D. Buchanan, Noralane M. Lindor, Finlay A. Macrae, Mark Clendenning, Yoland C. Antill, Stephen N. Thibodeau, Graham Casey, Steve Gallinger, Loic Le Marchand, Polly A. Newcomb, Robert W. Haile, Graeme P. Young, Paul A. James, Graham G. Giles, Shanaka R. Gunawardena, Barbara A. Leggett, Michael Gattas, Alex Boussioutas, Dennis J. Ahnen, John A. Baron, Susan Parry, Jack Goldblatt, Joanne P. Young, John L. Hopper and Mark A. Jenkins Cancer Risks for MLH1 and MSH2 Mutation Carriers Human Mutation 34

Version of Record online: 18 FEB 2013 | DOI: 10.1002/humu.22262

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Our estimates of colorectal and endometrial cancer risks for MLH1 and MSH2 mutation carriers are the most precise currently available. Average risks are similar for the two genes but there is so much individual variation about the average that a sizeable proportion of carries are almost certain to develop cancer whereas another sizeable proportion only have population-level risks.

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