Radhakrishnan Sabarinathan, Hakim Tafer, Stefan E. Seemann, Ivo L. Hofacker, Peter F. Stadler and Jan Gorodkin RNAsnp: Efficient Detection of Local RNA Secondary Structure Changes Induced by SNPs Human Mutation 34
Structural characteristics are essential for the functioning of many non-coding RNAs and cis-regulatory elements of mRNAs. Predictions of the significance of sequence variants on structural effects were made using RNAsnp on a dataset of 30 known SNPs reported to have a structural effect. The four experimentally validated SNPs were correctly predicted with this application (p-value < 0.1).
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