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Vincent Castella, Joëlle Gervaix and Diana Hall DIP–STR: Highly Sensitive Markers for the Analysis of Unbalanced Genomic Mixtures Human Mutation 34

Version of Record online: 5 MAR 2013 | DOI: 10.1002/humu.22280

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Here we propose a new genetic marker, named DIP-STR that enables the analysis of DNA mixtures containing highly unbalanced proportions of DNA from two individuals. This new tool is characterized by several remarkable features: (1) capacity of detecting a minor DNA contributing less than 0.1%; (2) equal performances regardless the sex of the DNA donors; (3) high discrimination power for identity testing; finally (4) simple and low cost genotyping technique. Applications may include forensics, prenatal diagnosis and organ transplant monitoring.

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