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Michael L. Nickerson, Kate M. Im, Kevin J. Misner, Wei Tan, Hong Lou, Bert Gold, David W. Wells, Hector C. Bravo, Karin M. Fredrikson, Timothy T. Harkins, Patrice Milos, Berton Zbar, W. Marston Linehan, Meredith Yeager, Thorkell Andresson, Michael Dean and G. Steven Bova Somatic Alterations Contributing to Metastasis of a Castration-Resistant Prostate Cancer Human Mutation 34

Version of Record online: 3 JUN 2013 | DOI: 10.1002/humu.22346

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We sequenced the exomes of five metastatic tumors and healthy kidney tissue from a mCRPC index case to identify lesions associated with disease progression and metastasis. The majority of somatic nonsynonymous variants were present in all metastases and only a subset was observed in the primary tumor. Somatic variants in individual tumors permitted us to infer a chronology for the clonal spread of disease based on sequential accrual of lesions. TET2 alteration or loss may define a subset of mCRPC.

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