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David B Mayfield, Mark S Johnson, Janet A Burris and Anne Fairbrother Furthering the derivation of predictive wildlife toxicity reference values for use in soil cleanup decisions Integrated Environmental Assessment and Management 10

Version of Record online: 21 NOV 2013 | DOI: 10.1002/ieam.1474

Key Points

  • Recent scientific advancements for developing species- and site-specific wildlife toxicity reference values (TRVs) for soil cleanup decisions allow for more realistic cleanup levels, as opposed to more general screening values.
  • TRVs are improved through incorporating local environmental factors, bioavailability differences between laboratory and field diets, appropriate endpoint selection, and dose-response information needed for parameterizing population models.
  • Interspecies extrapolation requires knowledge about physiological pathways, mode of action, mechanism of toxicity, and toxicokinetics; and as a rule, when physiological differences are profound, interspecies extrapolation is not recommended.
  • The application of generic safety or uncertainty factors should be considered as a risk management decision and not a scientifically based recommendation.

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