María Dolores Giráldez, Juan José Lozano, Míriam Cuatrecasas, Virginia Alonso-Espinaco, Joan Maurel, Maribel Mármol, Carlos Hörndler, Javier Ortego, Vicente Alonso, Pilar Escudero, Gina Ramírez, Christoph Petry, Luis LaSalvia, Kerstin Bohmann, Ralph Wirtz, Aurea Mira and Antoni Castells Gene-expression signature of tumor recurrence in patients with stage II and III colon cancer treated with 5′fluoruracil-based adjuvant chemotherapy International Journal of Cancer 132
Article first published online: 12 AUG 2012 | DOI: 10.1002/ijc.27747
A disappointing proportion of patients with colon cancer who received adjuvant chemotherapy after radical surgery will nonetheless develop tumor recurrence. Patients' chances of relapse are currently being predicted using pathological staging, and additional markers are needed to help select high-risk patients. This study identified a new gene-expression signature that, along with tumor stage, provides a robust and easy-to-use and reliable mathematical algorithm to identify patients at higher risk of tumor relapse and shorter survival who may eventually benefit from a more aggressive therapeutic regimen and more intensive surveillance.
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