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Qiangwei Fu, Steven E. Cash, Jeremiah J. Andersen, Colin R. Kennedy, Darby G. Oldenburg, Valerie B. Zander, Greta R. Foley and Carl Simon Shelley CD43 in the nucleus and cytoplasm of lung cancer is a potential therapeutic target International Journal of Cancer 132

Version of Record online: 29 OCT 2012 | DOI: 10.1002/ijc.27873

What's new?

Because the glycoprotein CD43 can have diametrically opposite functions in the same cell, it has been compared to Janus, the Roman god with two faces. Although it is normally expressed only in leukocytes, CD43 has also been found in lung cancer cells. In this study, the authors identified four subcategories of lung cancer based on expression patterns of CD43, thus providing a new molecular classification system. In addition, data from RNA interference experiments suggest that CD43 may be a valuable therapeutic target in lung cancer.

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