Muy-Teck Teh, Iain L. Hutchison, Daniela Elena Costea, Evelyn Neppelberg, Per Gunnar Liavaag, Karin Purdie, Catherine Harwood, Hong Wan, Edward W. Odell, Allan Hackshaw and Ahmad Waseem Exploiting FOXM1-orchestrated molecular network for early squamous cell carcinoma diagnosis and prognosis International Journal of Cancer 132
Early detection of pre-cancer lesions would greatly improve outcomes in head and neck squamous cell carcinoma (HSNCC), if it were possible to predict which lesions were likely to progress to cancer. Conventional histopathology is not up to the task, and this paper demonstrates a new molecular method for HSNCC detection. Using 14 genes associated with the FOXM1 oncogene, the authors created a diagnostic index capable of objectively stratifying cancer aggressiveness. They demonstrated a high detection rate and low false positive rate in classifying clinical tissue samples, making this system a practical diagnostic tool to improve patient outcomes.
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