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Yiqiang Zhao, Aaron J. Schetter, Geoffrey B. Yang, Giang Nguyen, Ewy A. Mathé, Peng Li, Hong Cai, Lei Yu, Fangfang Liu, Dong Hang, Haijun Yang, Xin Wei Wang, Yang Ke and Curtis C. Harris microRNA and inflammatory gene expression as prognostic marker for overall survival in esophageal squamous cell carcinoma International Journal of Cancer 132

Article first published online: 17 DEC 2012 | DOI: 10.1002/ijc.27954

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Esophageal cancer is the fifth leading cause of cancer-related deaths in men and the eighth leading cause in women worldwide. This study examined the potential of using microRNA and inflammatory gene expression patterns as prognostic classifiers for esophageal squamous cell carcinoma (ESCC). The data showed that microRNA and inflammatory gene expression patterns are associated with prognosis in ESCC, suggesting that they could be developed, alone or in combination, as prognostic classifiers to guide therapeutic decisions. If these microRNAs or inflammatory genes are mechanistically involved in ESCC cancer progression, development of therapies based on these genes may also be appropriate.

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