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Madeleine M.A. Tilanus-Linthorst, Hester F. Lingsma, D. Gareth Evans, Deborah Thompson, Reinoutje Kaas, Peggy Manders, Christi J. van Asperen, Muriel Adank, Maartje J. Hooning, Gek E. Kwan Lim, Rosalind Eeles, Jan C. Oosterwijk, Martin O. Leach and Ewout W. Steyerberg Optimal age to start preventive measures in women with BRCA1/2 mutations or high familial breast cancer risk International Journal of Cancer 133

Version of Record online: 13 FEB 2013 | DOI: 10.1002/ijc.28014

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Our study shows, that beside risk group also age at diagnosis in family members is predictive for age at onset in BRCA1 and 2 mutation carriers and women with familial risk. 14% of the variance in age at diagnosis, and in BRCA1 even 23%, was explained by family history versus 7% by risk group. This may be taken into account when determining the starting age for screening or other preventive measures.

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