C.A. Drukker, J.M. Bueno-de-Mesquita, V.P. Retèl, W.H. van Harten, H. van Tinteren, J. Wesseling, R.M.H. Roumen, M. Knauer, L.J. van 't Veer, G.S. Sonke, E.J.T. Rutgers, M.J. van de Vijver and S.C. Linn A prospective evaluation of a breast cancer prognosis signature in the observational RASTER study International Journal of Cancer 133
The “MammaPrint” is a 70-gene signature developed to predict the risk of breast cancer metastases. This study, the RASTER study, provides the first prospective data looking at this 70-gene signature to evaluate it's performance. For 427 patients, treatment decisions were based on standard guidelines, the 70-gene signature, and doctors' and patients' preferences. Here, 124 patients were categorized as “low-risk” by the 70-gene signature, but high-risk by other measures, such as age, tumor size, nodal status, and other clinicopathological factors. Of these, 76% did not receive adjuvant chemotherapy, and 98% survived 5 years with no recurrence of disease. Thus, withholding chemotherapy based on the low-risk gene signature result, and in accordance with doctors' and patients' preferences, did not negatively impact recurrence rate, confirming the prognostic value of this new tool.
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