Kristina Althoff, Anneleen Beckers, Andrea Odersky, Pieter Mestdagh, Johannes Köster, Isabella M. Bray, Kenneth Bryan, Jo Vandesompele, Frank Speleman, Raymond L. Stallings, Alexander Schramm, Angelika Eggert, Annika Sprüssel and Johannes H. Schulte MiR-137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1A International Journal of Cancer 133
Version of Record online: 7 MAR 2013 | DOI: 10.1002/ijc.28091
The protein KDM1A is strongly expressed in neuroblastomas. Overexpression of this protein correlates with poor patient prognosis, as does reduced expression of the microRNA miR-137. In this study, the authors examined whether miR-137 might act as a tumor suppressor in neuroblastoma, via the down-regulation of KDM1A. Their data led them to conclude that miR-137 does directly target KDM1A mRNA levels in neuroblastoma cells. In addition, increasing the expression of miR-137 resulted in increased apoptosis and decreased cell proliferation of neuroblastoma cells. This may provide a promising therapeutic strategy for aggressive neuroblastomas.
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