Françoise Degoul, Michèle Borel, Nathalie Jacquemot, Sophie Besse, Yves Communal, Florence Mishellany, Janine Papon, Frédérique Penault-Llorca, Denise Donnarieix, Michel Doly, Lydia Maigne, Elisabeth Miot-Noirault, Anne Cayre, Jacques Cluzel, Nicole Moins, Jean-Michel Chezal and Mathilde Bonnet In vivo efficacy of melanoma internal radionuclide therapy with a 131I-labelled melanin-targeting heteroarylcarboxamide molecule International Journal of Cancer 133
Article first published online: 18 MAR 2013 | DOI: 10.1002/ijc.28103
Currently, there is no effective treatment for disseminated melanoma. In this study, the authors found that a 131I-labelled heteroarylcarboxamide molecule called [131I]ICF01012 was effective in killing melanoma cells in an in vivo mouse model, with low toxicity. Molecular analyses of treated tumors revealed features consistent with a tumor-cell death mechanism of mitotic catastrophe. This targeted radionuclide therapy (TRT) offers a promising alternative to conventional therapeutic agents.
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