Mario Roselli, Patrizia Ferroni, Silvia Riondino, Sabrina Mariotti, Anastasia Laudisi, Matteo Vergati, Francesco Cavaliere, Raffaele Palmirotta and Fiorella Guadagni Impact of chemotherapy on activated protein C-dependent thrombin generation—Association with VTE occurrence International Journal of Cancer 133
Chemotherapy has been associated with an increased risk of venous thromboembolism (VTE). However, the prevalence of coagulation abnormalities or VTE occurrence as a consequence of different anti-cancer agents is largely uncharacterized. Here the authors find that use of platinum-based regimens is responsible for induction of an acquired thrombophilic condition (resistance to the anti-coagulant Activated Protein C) and represents a predictor for VTE even after adjustment for other risk factors. Monitoring coagulation changes during the first chemotherapy cycle, more than the determination of a single point measurement at baseline, might also help to identify patients susceptible of developing VTE during treatment.
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