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Mario Roselli, Patrizia Ferroni, Silvia Riondino, Sabrina Mariotti, Anastasia Laudisi, Matteo Vergati, Francesco Cavaliere, Raffaele Palmirotta and Fiorella Guadagni Impact of chemotherapy on activated protein C-dependent thrombin generation—Association with VTE occurrence International Journal of Cancer 133

Version of Record online: 16 MAR 2013 | DOI: 10.1002/ijc.28104

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Chemotherapy has been associated with an increased risk of venous thromboembolism (VTE). However, the prevalence of coagulation abnormalities or VTE occurrence as a consequence of different anti-cancer agents is largely uncharacterized. Here the authors find that use of platinum-based regimens is responsible for induction of an acquired thrombophilic condition (resistance to the anti-coagulant Activated Protein C) and represents a predictor for VTE even after adjustment for other risk factors. Monitoring coagulation changes during the first chemotherapy cycle, more than the determination of a single point measurement at baseline, might also help to identify patients susceptible of developing VTE during treatment.

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