Anupam Bishayee, Animesh Mandal, Roslin J. Thoppil, Altaf S. Darvesh and Deepak Bhatia Chemopreventive effect of a novel oleanane triterpenoid in a chemically induced rodent model of breast cancer International Journal of Cancer 133
Due to the long-term toxicity of prophylactic treatments for breast cancer such as tamoxifen and raloxifene, new chemopreventive therapies that have acceptable efficacy and toxicity profiles are urgently needed. In this study, the authors investigated whether a novel triterpenoid called “methyl amooranin” (AMR-Me) could prevent chemically-induced mammary tumors in rats. They found that AMR-Me exerted a striking chemopreventive effect, suppressing tumor-cell proliferation and inducing apoptosis. AMR-Me may thus represent a less toxic alternative for chemoprevention of breast cancer.
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