Xiaopan Wu, Zhenhui Xin, Wei Zhang, Jia Wu, Kangmei Chen, Huifen Wang, Xilin Zhu, Liping Pan, Zhuo Li, Hui Li and Ying Liu Polymorphisms in the VEGFA promoter are associated with susceptibility to hepatocellular carcinoma by altering promoter activity International Journal of Cancer 133
Genetic variations in vascular endothelial growth factor A (VEGFA) have been implicated in susceptibility to certain cancers and may explain the factor's involvement in tumor growth and metastasis. Here, two single nucleotide polymorphisms (SNPs), rs833601 and rs 1570360, identified in the promoter region of the VEGFA gene were found to be strongly associated with hepatitis B virus-related hepatocellular carcinoma (HCC) in Han Chinese populations. HCC patients were observed to have elevated VEGFA transcription, suggesting that the SNPs may contribute to HCC susceptibility by altering promoter activity.
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