Li-Sha Ai, Chun-Yan Sun, Ya-Dan Wang, Lu Zhang, Zhang-Bo Chu, You Qin, Fei Gao, Han Yan, Tao Guo, Lei Chen, Di Yang and Yu Hu Gene silencing of the BDNF/TrkB axis in multiple myeloma blocks bone destruction and tumor burden in vitro and in vivo International Journal of Cancer 133
The recent association of brain-derived neurotrophic factor (BDNF) with bone disease in multiple myeloma could have important therapeutic implications, though how the factor exerts its effects has remained unclear. Here, binding of multiple myeloma-derived BDNF to tyrosine receptor kinase B (TrkB) on osteoblasts was linked to increased RANKL and decreased OPG expression, thereby tipping the balance of these essential mediators of osteoclastogenesis toward increased bone resorption. Antisense inhibition of endogenous BDNF in multiple myeloma cells prevented bone destruction, angiogenesis, and tumor burden in vivo.
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