Takeshi Ishikawa, Satoshi Kokura, Naoyuki Sakamoto, Tetsuya Okayama, Masahiro Endo, Reiko Tsuchiya, Manabu Okajima, Tatsuzo Matsuyama, Satoko Adachi, Kazuhiro Kamada, Kazuhiro Katada, Kazuhiko Uchiyama, Osamu Handa, Tomohisa Takagi, Nobuaki Yagi, Takashi Ando, Kazuko Uno, Yuji Naito and Toshikazu Yoshikawa Whole blood interferon-γ levels predict the therapeutic effects of adoptive T-cell therapy in patients with advanced pancreatic cancer International Journal of Cancer 133
Article first published online: 29 MAR 2013 | DOI: 10.1002/ijc.28117
The study addresses a critical challenge in immune-based treatments of cancers: finding an easily accessible blood test that can predict a patient's responsiveness to treatment. The authors tested various cytokine and T cell parameters in patients afflicted with pancreatic cancer after receiving adoptive T cell therapy. They find that changes in whole blood interferon-gamma (IFN-γ) levels were independent variables predicting overall survival. Although a whole blood IFN-γ assay is considered a “nonspecific” immunological test, it faithfully reflected the patients' actual immune responses and should be especially valuable in situations where the relevant target antigen of the adoptively transferred T cells is not known. By combining measurements of whole blood IFN-γ with antigen-specific immunological assays, the authors hope to even better predict clinical outcome in cancer immunotherapy.
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