Hiroshi Aketa, Tomohide Tatsumi, Keisuke Kohga, Hinako Tsunematsu, Satoshi Aono, Satoshi Shimizu, Takahiro Kodama, Takatoshi Nawa, Minoru Shigekawa, Hayato Hikita, Ryotaro Sakamori, Atsushi Hosui, Takuya Miyagi, Naoki Hiramatsu, Tatsuya Kanto, Norio Hayashi and Tetsuo Takehara The combination therapy of α-galactosylceramide and 5-fluorouracil showed antitumor effect synergistically against liver tumor in mice International Journal of Cancer 133
Version of Record online: 13 MAR 2013 | DOI: 10.1002/ijc.28118
α-Galactosylceramide (α-GalCer) is effective against metastatic liver tumors in mice. In this study, the authors evaluated the antitumor effect of a combination therapy of α-GalCer plus 5-FU. They found that the combination therapy produced synergistic antitumor effects against liver tumors of colon cancer cells in mice, by both increasing the activation of natural killer (NK) cells and enhancing the sensitivity of the cancer cells to those NK cells. This combination may therefore represent a promising new chemo-immunotherapy against metastatic liver cancer.
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