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Yong-June Kim, Hyung-Yoon Yoon, Ji Sang Kim, Ho Won Kang, Byung-Dal Min, Seon-Kyu Kim, Yun-Sok Ha, Isaac Yi Kim, Keun Ho Ryu, Sang-Cheol Lee and Wun-Jae Kim HOXA9, ISL1 and ALDH1A3 methylation patterns as prognostic markers for nonmuscle invasive bladder cancer: Array-based DNA methylation and expression profiling International Journal of Cancer 133

Article first published online: 16 MAR 2013 | DOI: 10.1002/ijc.28121

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Many patients with non-muscle invasive bladder cancer (NMIBC) are at high risk of disease recurrence and progression after primary treatment. Clinicians thus have to develop both cost-effective, non-invasive surveillance protocols for low-risk patients and more aggressive approaches to identify high-risk refractory cancers. This study used microarray-based methylation and expression profiling to identify novel prognostic methylation markers associated with clinicopathological tumor characteristics and disease outcomes. The presented candidate genes are the first methylation-based prognostic indicators for NMIBC. Epigenetic markers could be valuable tools for stratifying heterogeneous bladder cancer patient populations into risk groups, which in turn could help guide clinical decisions.

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