Dhwanil Damania, Hemant K. Roy, Dhananja Kunte, Jean A. Hurteau, Hariharan Subramanian, Lusik Cherkezyan, Nela Krosnjar, Maitri Shah and Vadim Backman Insights into the field carcinogenesis of ovarian cancer based on the nanocytology of endocervical and endometrial epithelial cells International Journal of Cancer 133
Ovarian cancer is frequently fatal because it is not detected until it has progressed to late-stage metastatic disease, and new techniques for early detection are sorely needed. Sometimes, apparently normal cells can undergo changes similar to the cancer cells, in a phenomenon called “field carcinogenesis.” In these instances, multiple cancers arise in different sites within the same region. In this paper, the authors employ a novel technique, partial wave spectroscopy (PWS) to detect ovarian field carcinogenesis by looking for nanoscale changes in the architecture of endometrial and cervical cells. This report signifies the first demonstration that PWS nanocytology can detect cellular structures at such a small scale. Using this technique to detect ovarian field carcinogenesis could represent a minimally invasive approach to early intervention for ovarian cancer.
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