Yu Zhou, Quanbo Zhou, Qing Lin, Ruiwan Chen, Yuanfeng Gong, Yimin Liu, Min Yu, Bing Zeng, Kaiwen Li, Rufu Chen and Zhihua Li Evaluation of risk factors for extrahepatic cholangiocarcinoma: ABO blood group, hepatitis B virus and their synergism International Journal of Cancer 133
Hepatitis B virus (HBV) infection is a suspected risk factor for extrahepatic cholangiocarcinoma (ECC), though how it gives rise to malignant disease of the bile ducts situated outside the liver is unclear. Here, a significant association was found for HBV infection, A blood type, and ECC risk in the Han Chinese ethnic group of Southern China. Compared with non-A blood group ECC patients, type A ECC patients tended to be younger and had lower CA-125 and CA19-9 levels. The study is the first to confirm an association between A blood group, HBV, and ECC risk.
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